Hello JCinWV,
My first thought was that the water in your your sink and shower P traps had evaporated, letting in septic gasses and odors. Try running a little water (a few cups) in the shower and sink once in a while to make sure these traps have water in them. See if that help.
It is also possible that your roof vent is wafting odors into this upstairs bathroom. Is your window open when the smells occur??
If so, you might want to shut the window

or try extending the roof vent on top of the house a few feet. This can be done by using a pvc pipe that is the same size as your roof vent and a simple PVC fitting. You don't even have to glue it. Just slip in on there good and tight and see if it helps your problems. If not, you can easily remove the extension.
Stuart